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Issue 13, 2014
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From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

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Abstract

We present a portable, battery-operated and application-specific lab-on-a-chip (ASLOC) system that can be easily configured for a wide range of lab-on-a-chip applications. It is based on multiplexed electrical current detection that serves as the sensing system. We demonstrate different configurations to perform most detection schemes currently in use in LOC systems, including some of the most advanced such as nanowire-based biosensing, surface plasmon resonance sensing, electrochemical detection and real-time PCR. The complete system is controlled by a single chip and the collected information is stored in situ, with the option of transferring the data to an external display by using a USB interface. In addition to providing a framework for truly portable real-life developments of LOC systems, we envisage that this system will have a significant impact on education, especially since it can easily demonstrate the benefits of integrated microanalytical systems.

Graphical abstract: From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

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Article information


Submitted
12 Mar 2014
Accepted
25 Mar 2014
First published
25 Mar 2014

This article is Open Access

Lab Chip, 2014,14, 2168-2176
Article type
Paper
Author version available

From chip-in-a-lab to lab-on-a-chip: towards a single handheld electronic system for multiple application-specific lab-on-a-chip (ASLOC)

P. Neužil, C. D. M. Campos, C. C. Wong, J. B. W. Soon, J. Reboud and A. Manz, Lab Chip, 2014, 14, 2168
DOI: 10.1039/C4LC00310A

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    [Original citation] - Published by The Royal Society of Chemistry.

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