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Issue 5, 2014
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Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives

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Abstract

An efficient methodology to oxidize β,β-dihalogenated secondary alcohols employing oxygen was achieved in a biphasic medium using the laccase from Trametes versicolor/TEMPO pair, providing the corresponding ketones in a clean fashion under very mild conditions. Moreover, a chemoenzymatic protocol has been applied successfully to deracemize 2,2-dichloro-1-phenylethanol combining this oxidation with an alcohol dehydrogenase-catalyzed bioreduction.

Graphical abstract: Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives

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Publication details

The article was received on 14 Jan 2014, accepted on 19 Feb 2014 and first published on 19 Feb 2014


Article type: Communication
DOI: 10.1039/C4GC00066H
Green Chem., 2014,16, 2448-2453

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    Laccase/TEMPO-mediated system for the thermodynamically disfavored oxidation of 2,2-dihalo-1-phenylethanol derivatives

    K. Kędziora, A. Díaz-Rodríguez, I. Lavandera, V. Gotor-Fernández and V. Gotor, Green Chem., 2014, 16, 2448
    DOI: 10.1039/C4GC00066H

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