Issue 7, 2014

Conjugated linolenic acids and their bioactivities: a review

Abstract

Conjugated linolenic acid (CLNA) is a mixture of positional and geometric isomers of octadecatrienoic acid (α-linolenic acid, cis9,cis12,cis15–18:3 n-3) found in plant seeds. Three 8,10,12–18:3 isomers and four 9,11,13–18:3 isomers have been reported to occur naturally. CLNA isomers such as punicic acid, α-eleostearic acid and jacaric acid have been attributed to exhibit several health benefits that are largely based on animal and in vitro studies. This review has summarized and updated the evidence regarding the metabolism and bioactivities of CLNA isomers, and comprehensively discussed the recent studies on the effects of anti-carcinogenic, lipid metabolism regulation, anti-inflammatory, anti-obese and antioxidant activities of CLNA isomers. The available results may provide a potential application for CLNA isomers from natural sources, especially edible plant seeds, as effective functional food ingredients and dietary supplements for the above mentioned disease management. Further research, especially human randomized clinical trials, is warranted to investigate the detailed physiological effects, bioactivity and molecular mechanism of CLNA.

Graphical abstract: Conjugated linolenic acids and their bioactivities: a review

Article information

Article type
Review Article
Submitted
16 Jan 2014
Accepted
28 Feb 2014
First published
03 Mar 2014

Food Funct., 2014,5, 1360-1368

Conjugated linolenic acids and their bioactivities: a review

G. Yuan, Xiao-E. Chen and D. Li, Food Funct., 2014, 5, 1360 DOI: 10.1039/C4FO00037D

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