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Issue 4, 2014
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Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action

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Abstract

Dietary constituents are shown to play an important role in the development of diabetes. Studies have shown that the fruits of Emblica officinalis Gaertn or Phyllanthus emblica Linn, colloquially known as Indian gooseberry or amla and/or some of its important constituents (including gallic acid, gallotanin, ellagic acid and corilagin), possess anti-diabetic effects through their antioxidant and free radical scavenging properties. Amla has also been reported to prevent/reduce hyperglycemia, cardiac complications, diabetic nephropathy, neuropathy, cataractogenesis and protein wasting. However, clinical trial data with human subjects are limited and preliminary. For the first time this review summarizes the anti-diabetic affects of amla and also addresses the mechanisms mediating these properties.

Graphical abstract: Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action

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Article information


Submitted
28 Aug 2013
Accepted
11 Jan 2014
First published
28 Feb 2014

Food Funct., 2014,5, 635-644
Article type
Review Article

Anti-diabetic effects of the Indian indigenous fruit Emblica officinalis Gaertn: active constituents and modes of action

J. J. D'souza, P. P. D'souza, F. Fazal, A. Kumar, H. P. Bhat and M. S. Baliga, Food Funct., 2014, 5, 635
DOI: 10.1039/C3FO60366K

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