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Issue 26, 2014
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Syntheses and structural investigation of some alkali metal ion-mediated LVVO2 (L2− = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities

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Abstract

Eight alkali metal ion-mediated dioxidovanadium(V), [{VVO2L1−6}A(H2O)n], complexes for A = Li+, Na+, K+ and Cs+, containing tridentate aroylhydrazonate ligands coordinating via ONO donor atoms, are described. All the synthesised ligands and the metal complexes were successfully characterised by elemental analysis, IR, UV-Vis and NMR spectroscopy. X-ray crystallographic investigation of 3, 5–7 shows the presence of distorted NO4 coordination geometries for LVO2 in each case, and varying μ-oxido and/or μ-aqua bridging with interesting variations correlated with the size of the alkali metal ions: with small Li+, no bridging-O is found but four ion aggregates are found with Na+, chains for K+ and finally, layers for Cs+. Two (5) or three-dimensional (3, 6 and 7) architectures are consolidated by hydrogen bonding. The dioxidovanadium(V) complexes were found to exhibit DNA binding activity due to their interaction with CT-DNA by the groove binding mode, with binding constants ranging from 103 to 104 M−1. Complexes 1–8 were also tested for DNA nuclease activity against pUC19 plasmid DNA which showed that 6 and 7 had the best DNA binding and photonuclease activity; these results support their good protein binding and cleavage activity with binding constants ranging from 104 to 105 M−1. Finally, the in vitro antiproliferative activity of all complexes was assayed against the HeLa cell line. Some of the complexes (2, 5, 6 and 7) show considerable activity compared to commonly used chemotherapeutic drugs. The variation in cytotoxicity of the complexes is influenced by the various functional groups attached to the aroylhydrazone derivative.

Graphical abstract: Syntheses and structural investigation of some alkali metal ion-mediated LVVO2− (L2− = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities

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Supplementary files

Article information


Submitted
25 Mar 2014
Accepted
09 May 2014
First published
09 May 2014

Dalton Trans., 2014,43, 10139-10156
Article type
Paper

Syntheses and structural investigation of some alkali metal ion-mediated LVVO2 (L2− = tridentate ONO ligands) species: DNA binding, photo-induced DNA cleavage and cytotoxic activities

S. P. Dash, A. K. Panda, S. Pasayat, R. Dinda, A. Biswas, E. R. T. Tiekink, Y. P. Patil, M. Nethaji, W. Kaminsky, S. Mukhopadhyay and S. K. Bhutia, Dalton Trans., 2014, 43, 10139
DOI: 10.1039/C4DT00883A

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