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Issue 22, 2014
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Benzyl-substituted metallocarbene antibiotics and anticancer drugs

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Abstract

Benzyl-substituted metallocarbene compounds synthesised by our group and others during the past 5 years give a new perspective on their activity as antibiotic and antitumoral drugs. N-heterocyclic carbenes containing an imidazole core were functionalised and their transition metal complexes (M = Ag, Au, Cu, Ru) have shown promising antibacterial as well as anticancer activity in vitro and in vivo. IC50 values in the nanomolar region or antibacterial activity comparable to conventional antibiotics lead the way towards novel drug candidates.

Graphical abstract: Benzyl-substituted metallocarbene antibiotics and anticancer drugs

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Publication details

The article was received on 28 Feb 2014, accepted on 03 Apr 2014 and first published on 03 Apr 2014


Article type: Perspective
DOI: 10.1039/C4DT00624K
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Dalton Trans., 2014,43, 8144-8153

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    Benzyl-substituted metallocarbene antibiotics and anticancer drugs

    F. Hackenberg and M. Tacke, Dalton Trans., 2014, 43, 8144
    DOI: 10.1039/C4DT00624K

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