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Issue 21, 2014
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Rational development of iron catalysts for asymmetric transfer hydrogenation

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Abstract

The asymmetric reduction of ketones and imines by transfer of hydrogen from isopropanol as the solvent catalyzed by metal complexes is a very useful method for preparing valuable enantioenriched alcohols and amines. Described here is the development of three generations of progressively more active iron catalysts for this transformation. Key features of this process of discovery involved the realization that one carbonyl ligand was needed (as in hydrogenases), the synthesis of modular ligands templated by iron, the elucidation of the mechanisms of catalyst activation and action, as well as the rational synthesis of precursors that lead directly and easily to the species in the catalytic cycle. The discovery that iron, an abundant element that is essential to life, can form catalysts of these hydrogenation reactions is a contribution to green chemistry.

Graphical abstract: Rational development of iron catalysts for asymmetric transfer hydrogenation

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Article information


Submitted
27 Feb 2014
Accepted
14 Apr 2014
First published
15 Apr 2014

This article is Open Access

Dalton Trans., 2014,43, 7650-7667
Article type
Perspective

Rational development of iron catalysts for asymmetric transfer hydrogenation

P. E. Sues, K. Z. Demmans and R. H. Morris, Dalton Trans., 2014, 43, 7650
DOI: 10.1039/C4DT00612G

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