Issue 26, 2014
From the journal:

Dalton Transactions

Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform†

Shruti Khanna,a   Batakrishna Jana,b   Abhijit Saha,b   Prashant Kurkute,b   Surajit Ghosh*b  and  Sandeep Verma*ac  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India
E-mail: sverma@iitk.ac.in

b Chemistry Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Kolkata 700 032, WB, India
E-mail: sghosh@iicb.res.in

c DST Thematic Unit of Excellence on Soft Nanofabrication, Centre for Environmental Sciences and Engineering, Indian Institute of Technology Kanpur, Kanpur 208016, India

Abstract

This communication describes the synthesis, structural investigation and tubulin binding of purine rare imino-tautomer based Ag(I) and Hg(II)–carbene complexes. These complexes exhibit cytotoxicity through tubulin interaction by binding to a site close to the GTP binding site.

Graphical abstract: Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform

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Article information

DOI
https://doi.org/10.1039/C4DT00529E
Article type
Communication
Submitted
20 Feb 2014
Accepted
09 Apr 2014
First published
09 Apr 2014

Dalton Trans., 2014,43, 9838-9842

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Targeting cytotoxicity and tubulin polymerization by metal–carbene complexes on a purine tautomer platform

S. Khanna, B. Jana, A. Saha, P. Kurkute, S. Ghosh and S. Verma, Dalton Trans., 2014, 43, 9838 DOI: 10.1039/C4DT00529E

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