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Issue 14, 2014
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Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

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Abstract

A new turn-on cell permeable chemodosimetric probe 1 has been developed and its application in the selective detection of trivalent cations (Fe3+/Cr3+/Al3+) at a sub-nanomolar level has been demonstrated. The selectivity of 1 over a broad spectrum of mono- and divalent metal ions was established using fluorescence spectroscopy. Moreover, the changes in the absorption spectra of 1 in the presence of trivalent cations enabled the most bio-relevant metal ion Fe3+ over Cr3+/Al3+ to be distinguished. The probe was found to be successful in the fluorescence imaging of native cellular iron pools. The fluorescence imaging of the native iron pools of banana pith further supported the high sensitivity of 1 towards Fe3+ present in living systems. To the best of our knowledge, this is the first example of a turn-on chemodosimetric probe to image native cellular Fe3+ pools.

Graphical abstract: Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

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Publication details

The article was received on 06 Nov 2013, accepted on 19 Dec 2013 and first published on 24 Dec 2013


Article type: Communication
DOI: 10.1039/C3DT53141D
Dalton Trans., 2014,43, 5269-5273

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    Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

    M. Venkateswarulu, T. Mukherjee, S. Mukherjee and R. R. Koner, Dalton Trans., 2014, 43, 5269
    DOI: 10.1039/C3DT53141D

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