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Issue 19, 2014
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Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

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Abstract

The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease. Misfolding of proteins and peptides, as is the case with Aβ, follows a progression from a monomeric state, through intermediates, ending at long, unbranched amyloid fibers. This tutorial review offers a perspective on the association of toxic Aβ structures with membranes as well as details of membrane-associated mechanisms of toxicity.

Graphical abstract: Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

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Article information


Submitted
27 Nov 2013
First published
24 Jan 2014

Chem. Soc. Rev., 2014,43, 6692-6700
Article type
Tutorial Review
Author version available

Differences between amyloid-β aggregation in solution and on the membrane: insights into elucidation of the mechanistic details of Alzheimer's disease

S. A. Kotler, P. Walsh, J. R. Brender and A. Ramamoorthy, Chem. Soc. Rev., 2014, 43, 6692
DOI: 10.1039/C3CS60431D

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