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Issue 14, 2014
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Protein conformation as a regulator of cell–matrix adhesion

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The dynamic regulation of cell–matrix adhesion is essential for tissue homeostasis and architecture, and thus numerous pathologies are linked to altered cell–extracellular matrix (ECM) interaction and ECM scaffold. The molecular machinery involved in cell–matrix adhesion is complex and involves both sensory and matrix-remodelling functions. In this review, we focus on how protein conformation controls the organization and dynamics of cell–matrix adhesion. The conformational changes in various adhesion machinery components are described, including examples from ECM as well as cytoplasmic proteins. The discussed mechanisms involved in the regulation of protein conformation include mechanical stress, post-translational modifications and allosteric ligand-binding. We emphasize the potential role of intrinsically disordered protein regions in these processes and discuss the role of protein networks and co-operative protein interactions in the formation and consolidation of cell–matrix adhesion and extracellular scaffolds.

Graphical abstract: Protein conformation as a regulator of cell–matrix adhesion

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The article was received on 19 Nov 2013, accepted on 13 Jan 2014 and first published on 13 Jan 2014

Article type: Perspective
DOI: 10.1039/C3CP54884H
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Phys. Chem. Chem. Phys., 2014,16, 6342-6357

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    Protein conformation as a regulator of cell–matrix adhesion

    V. P. Hytönen and B. Wehrle-Haller, Phys. Chem. Chem. Phys., 2014, 16, 6342
    DOI: 10.1039/C3CP54884H

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