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Issue 18, 2014
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How DNA is damaged by external electric fields: selective mutation vs. random degradation

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Abstract

DNA is constantly exposed to exogenous agents that randomly damage the genetic code. However, external perturbations might also be used to induce malignant cell death if the mutation processes are controlled. The present communication reports a set of parameters allowing DNA mutation through the use of intense external electric fields. This is a step towards the design of pulsed electric field therapy for genetic diseases.

Graphical abstract: How DNA is damaged by external electric fields: selective mutation vs. random degradation

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Publication details

The article was received on 25 Oct 2013, accepted on 19 Nov 2013 and first published on 25 Nov 2013


Article type: Communication
DOI: 10.1039/C3CP54518K
Phys. Chem. Chem. Phys., 2014,16, 8243-8246

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    How DNA is damaged by external electric fields: selective mutation vs. random degradation

    J. P. Cerón-Carrasco, J. Cerezo and D. Jacquemin, Phys. Chem. Chem. Phys., 2014, 16, 8243
    DOI: 10.1039/C3CP54518K

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