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Issue 23, 2014
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Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

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Abstract

Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitantly on a control substrate under similar solution conditions.

Graphical abstract: Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

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Publication details

The article was received on 24 Dec 2013, accepted on 04 Mar 2014 and first published on 04 Mar 2014


Article type: Communication
DOI: 10.1039/C3CE42622J
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CrystEngComm, 2014,16, 4927-4930

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    Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

    J. V. Parambil, S. K. Poornachary, R. B. H. Tan and J. Y. Y. Heng, CrystEngComm, 2014, 16, 4927
    DOI: 10.1039/C3CE42622J

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