Issue 24, 2014

Tunable acid-sensitive ester protecting groups in oligosaccharide synthesis

Abstract

A series of acid-cleavable ester-type protecting groups, with acid-sensitivity profiles parallel to those of 2-naphthylmethyl (NAP) or p-methoxybenzyl (PMB) ether, were designed and TFA in toluene was identified as a technically simple and effective deblocking cocktail for their global removal in the context of oligosaccharide synthesis.

Graphical abstract: Tunable acid-sensitive ester protecting groups in oligosaccharide synthesis

Supplementary files

Article information

Article type
Communication
Submitted
03 Dec 2013
Accepted
20 Dec 2013
First published
23 Dec 2013

Chem. Commun., 2014,50, 3155-3158

Tunable acid-sensitive ester protecting groups in oligosaccharide synthesis

Y. Li and X. Liu, Chem. Commun., 2014, 50, 3155 DOI: 10.1039/C3CC49205B

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