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Issue 11, 2014
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Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

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Abstract

Nearly all concepts of nanocarriers as drug delivery devices rely on intracellular uptake. Instead, we demonstrate an alternative concept for rapid and specific delivery of cargo by nanoparticles to TIP47+/ADRP+ lipid droplets. The model can serve as a novel strategy for the non-invasive delivery of drugs by releasing hydrophobic cargo, in our case a model dye, through a kiss-and-run mechanism between nanoparticles and the cell membrane.

Graphical abstract: Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

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Supplementary files

Article information


Submitted
23 Oct 2013
Accepted
26 Nov 2013
First published
27 Nov 2013

This article is Open Access

Chem. Commun., 2014,50, 1369-1371
Article type
Communication

Drug delivery without nanoparticle uptake: delivery by a kiss-and-run mechanism on the cell membrane

D. Hofmann, C. Messerschmidt, M. B. Bannwarth, K. Landfester and V. Mailänder, Chem. Commun., 2014, 50, 1369
DOI: 10.1039/C3CC48130A

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