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Issue 95, 2016
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Rhodium catalyzed synthesis of difluoromethyl cyclopropanes

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Abstract

Difluoromethyl-substituted cyclopropanes still remain one of the most challenging class of substrates. Despite significant progress in modern chemistry, an atom-economic and concise synthesis has not been described to date. Herein, we describe the first method for their catalytic, one-step synthesis using difluoromethyl diazomethane and a rhodium(II) catalyst.

Graphical abstract: Rhodium catalyzed synthesis of difluoromethyl cyclopropanes

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Publication details

The article was received on 23 Sep 2016, accepted on 31 Oct 2016 and first published on 02 Nov 2016


Article type: Communication
DOI: 10.1039/C6CC07745E
Chem. Commun., 2016,52, 13783-13786
  • Open access: Creative Commons BY-NC license
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    Rhodium catalyzed synthesis of difluoromethyl cyclopropanes

    K. J. Hock, L. Mertens and R. M. Koenigs, Chem. Commun., 2016, 52, 13783
    DOI: 10.1039/C6CC07745E

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