Issue 89, 2014
From the journal:

Chemical Communications

A cytotoxic and cytostatic gold(iii) corrole

Ruijie D. Teo,ab   Harry B. Gray,*a   Punnajit Lim,b   John Termini,*b   Elena Domeshekc  and  Zeev Gross*c  

* Corresponding authors

a Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA
E-mail: hbgray@caltech.edu

b Department of Molecular Medicine, Beckman Research Institute of the City of Hope, 1500 E. Duarte Road, Duarte, California 91010, USA
E-mail: jtermini@coh.org

c Schulich Faculty of Chemistry, Technion—Israel Institute of Technology, Haifa 32000, Israel
E-mail: chr10zg@tx.technion.ac.il

Abstract

We have synthesized and characterized a water-soluble gold(III) corrole (1-Au) that is highly toxic to cisplatin-resistant cancer cells. Relative to its 1-Ga analogue, axial ligands bind only weakly to 1-Au, which likely accounts for its lower affinity for human serum albumin (HSA). We suggest that the cytotoxicity of 1-Au may be related to this lower HSA affinity.

Graphical abstract: A cytotoxic and cytostatic gold(iii) corrole

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Article information

DOI
https://doi.org/10.1039/C4CC06577H
Article type
Communication
Submitted
21 Aug 2014
Accepted
04 Sep 2014
First published
05 Sep 2014

Chem. Commun., 2014,50, 13789-13792

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A cytotoxic and cytostatic gold(III) corrole

R. D. Teo, H. B. Gray, P. Lim, J. Termini, E. Domeshek and Z. Gross, Chem. Commun., 2014, 50, 13789 DOI: 10.1039/C4CC06577H

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