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Issue 89, 2014
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Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

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Abstract

The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.

Graphical abstract: Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

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Publication details

The article was received on 14 Aug 2014, accepted on 08 Sep 2014 and first published on 08 Sep 2014


Article type: Communication
DOI: 10.1039/C4CC06371F
Chem. Commun., 2014,50, 13742-13745

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    Synthesis and properties of DNA oligonucleotides with a zwitterionic backbone structure

    B. Schmidtgall, A. P. Spork, F. Wachowius, C. Höbartner and C. Ducho, Chem. Commun., 2014, 50, 13742
    DOI: 10.1039/C4CC06371F

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