Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

There will be scheduled maintenance work beginning on Saturday 15th June 2019 at 8:30 am through to Sunday 16th June 2019 at 11:30 pm (BST).

During this time our website may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 100, 2014
Previous Article Next Article

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Author affiliations

Abstract

Antimicrobial drug discovery has slowed considerably over the last few decades. One major cause for concern is the lack of innovative approaches to treat infections caused by mycobacteria such as TB. Herein we demonstrate that our Small Molecule Variable Ligand Display (SMLVD) method for nanoparticle antibiotic discovery can be expanded around a ligand feed ratio parameter space to identify gold nanoparticle conjugates that are potent inhibitors of mycobacteria growth, with our most potent inhibitor able to reduce growth by five orders of magnitude at 8 μM.

Graphical abstract: Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Aug 2014, accepted on 18 Oct 2014 and first published on 20 Oct 2014


Article type: Communication
DOI: 10.1039/C4CC06236A
Author version
available:
Download author version (PDF)
Chem. Commun., 2014,50, 15860-15863

  •   Request permissions

    Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

    J. C. Gifford, J. Bresee, C. J. Carter, G. Wang, R. J. Melander, C. Melander and D. L. Feldheim, Chem. Commun., 2014, 50, 15860
    DOI: 10.1039/C4CC06236A

Search articles by author

Spotlight

Advertisements