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Issue 81, 2014
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Chemical modification of temoporfin – a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

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Abstract

LiYF4:Tm3+/Yb3+ upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death under 980 nm irradiation.

Graphical abstract: Chemical modification of temoporfin – a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

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Supplementary files

Article information


Submitted
29 Jul 2014
Accepted
19 Aug 2014
First published
01 Sep 2014

Chem. Commun., 2014,50, 12150-12153
Article type
Communication

Chemical modification of temoporfin – a second generation photosensitizer activated using upconverting nanoparticles for singlet oxygen generation

Q. Yu, E. M. Rodriguez, R. Naccache, P. Forgione, G. Lamoureux, F. Sanz-Rodriguez, D. Scheglmann and J. A. Capobianco, Chem. Commun., 2014, 50, 12150 DOI: 10.1039/C4CC05867D

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