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Issue 77, 2014
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A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

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Abstract

Metal chelators masked with protecting groups for targeted release have the potential to conditionally modulate cellular metals. We report a new route to prepare cis-cinnamate protecting groups that enabled development of a prochelator with chemical stimulus response, fluorescent reporting and active compound release in a single structure.

Graphical abstract: A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

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Supplementary files

Article information


Submitted
03 Jul 2014
Accepted
05 Aug 2014
First published
13 Aug 2014

Chem. Commun., 2014,50, 11317-11320
Article type
Communication
Author version available

A prochelator with a modular masking group featuring hydrogen peroxide activation with concurrent fluorescent reporting

A. T. Franks and K. J. Franz, Chem. Commun., 2014, 50, 11317
DOI: 10.1039/C4CC05076B

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