Issue 71, 2014
From the journal:

Chemical Communications

A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines†

Ho Yin Li,a   Joachim Horn,a   Amanda Campbell,b   David House,b   Adam Nelson*ac  and  Stephen P. Marsden*a  

* Corresponding authors

a School of Chemistry, University of Leeds, Leeds, UK
E-mail: a.s.nelson@leeds.ac.uk, s.p.marsden@leeds.ac.uk

b GlaxoSmithKline Medicines Research Centre, Stevenage, UK

c Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, UK

Abstract

Rh-catalysed conjugate additions of 2-aminophenyl boronic acid derivatives were exploited in diastereoselective and asymmetric syntheses of tetrahydroquinolines. In both cases, combinatorial variation of the substitution of the tetrahydroquinoline ring system was possible.

Graphical abstract: A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines

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Article information

DOI
https://doi.org/10.1039/C4CC04940C
Article type
Communication
Submitted
27 Jun 2014
Accepted
18 Jul 2014
First published
23 Jul 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 10222-10224

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A convergent rhodium-catalysed asymmetric synthesis of tetrahydroquinolines

H. Y. Li, J. Horn, A. Campbell, D. House, A. Nelson and S. P. Marsden, Chem. Commun., 2014, 50, 10222 DOI: 10.1039/C4CC04940C

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