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Issue 84, 2014
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Stereodefined acyclic trisubstituted metal enolates towards the asymmetric formation of quaternary carbon stereocentres

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Abstract

Reactions that involve metal enolate species are amongst the most versatile carbon–carbon bond forming processes available to synthetic chemists. Enolate species are involved in a multitude of powerful applications in asymmetric organic synthesis, but the generation of fully substituted enolates in a geometrically defined form is not easily achieved especially in acyclic systems. In this Feature Article we focus on the most prominent examples reported in the literature describing the formation of highly diastereo- and enantiomerically enriched quaternary stereocentres in acyclic molecules derived from stereodefined non-cyclic trisubstituted metal enolates.

Graphical abstract: Stereodefined acyclic trisubstituted metal enolates towards the asymmetric formation of quaternary carbon stereocentres

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Article information


Submitted
09 Jun 2014
Accepted
16 Jul 2014
First published
21 Jul 2014

Chem. Commun., 2014,50, 12597-12611
Article type
Feature Article
Author version available

Stereodefined acyclic trisubstituted metal enolates towards the asymmetric formation of quaternary carbon stereocentres

Y. Minko and I. Marek, Chem. Commun., 2014, 50, 12597
DOI: 10.1039/C4CC04391J

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