Issue 67, 2014

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Abstract

Herein, we describe a fast and robust method for achieving 68Ga-labelling of the EGFR-selective monoclonal antibody (mAb) Cetuximab using the bioorthogonal Inverse-electron-Demand Diels–Alder (IeDDA) reaction. The in vivo imaging of EGFR is demonstrated, as well as the translation of the method within a two-step pretargeting strategy.

Graphical abstract: A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

Supplementary files

Article information

Article type
Communication
Submitted
21 May 2014
Accepted
04 Jul 2014
First published
04 Jul 2014

Chem. Commun., 2014,50, 9557-9560

Author version available

A bioorthogonal 68Ga-labelling strategy for rapid in vivo imaging

H. L. Evans, Q. Nguyen, L. S. Carroll, M. Kaliszczak, F. J. Twyman, A. C. Spivey and E. O. Aboagye, Chem. Commun., 2014, 50, 9557 DOI: 10.1039/C4CC03903C

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