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Issue 80, 2014
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Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)–tetrazine reaction

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Abstract

By anchoring 1,2,4,5-tetrazine-containing biomolecules onto trans-cyclooctene (TCO)-functionalized slides, a site-specific microarray immobilization approach is described in this study. Compared with existing immobilization methods, our approach offers several distinctive features, including fast kinetics and high chemoselectivity.

Graphical abstract: Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)–tetrazine reaction

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Publication details

The article was received on 20 May 2014, accepted on 14 Jul 2014 and first published on 14 Jul 2014


Article type: Communication
DOI: 10.1039/C4CC03838J
Chem. Commun., 2014,50, 11818-11821

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    Microarray immobilization of biomolecules using a fast trans-cyclooctene (TCO)–tetrazine reaction

    P. Wang, Z. Na, J. Fu, C. Y. J. Tan, H. Zhang, S. Q. Yao and H. Sun, Chem. Commun., 2014, 50, 11818
    DOI: 10.1039/C4CC03838J

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