Issue 74, 2014
From the journal:

Chemical Communications

Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks†

Rocio Bueno-Perez,a   Ana Martin-Calvo,a   Paula Gómez-Álvarez,a   Juan J. Gutiérrez-Sevillano,b   Patrick J. Merkling,a   Thijs J. H. Vlugt,b   Titus S. van Erp,c   David Dubbeldamd  and  Sofia Calero ORCID logo *a  

* Corresponding authors

a University Pablo de Olavide, Ctra. Utrera km. 1, 41013 Seville, Spain
E-mail: scalero@upo.es

b Delft University of Technology, Process & Energy Department, Leeghwaterstraat 39, 2628 CB Delft, The Netherlands

c Department of Chemistry, Norwegian University of Science and Technology, 7941 Trondheim, Norway

d University of Amsterdam, Science Park 904, Amsterdam, The Netherlands

Abstract

This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

Graphical abstract: Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks

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Article information

DOI
https://doi.org/10.1039/C4CC03745F
Article type
Communication
Submitted
16 May 2014
Accepted
24 Jul 2014
First published
24 Jul 2014

Chem. Commun., 2014,50, 10849-10852

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Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks

R. Bueno-Perez, A. Martin-Calvo, P. Gómez-Álvarez, J. J. Gutiérrez-Sevillano, P. J. Merkling, T. J. H. Vlugt, T. S. van Erp, D. Dubbeldam and S. Calero, Chem. Commun., 2014, 50, 10849 DOI: 10.1039/C4CC03745F

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