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Issue 74, 2014
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Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks

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Abstract

This study reveals the efficient enantiomeric separation of bioactive molecules in the liquid phase. Chiral structure HMOF-1 separates racemic mixtures whereas heteroselectivity is observed for scalemic mixtures of ibuprofen using non-chiral MIL-47 and MIL-53. Lysine enantiomers are only separated by HMOF-1. These separations are controlled by the tight confinement of the molecules.

Graphical abstract: Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks

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Article information


Submitted
16 May 2014
Accepted
24 Jul 2014
First published
24 Jul 2014

Chem. Commun., 2014,50, 10849-10852
Article type
Communication

Enantioselective adsorption of ibuprofen and lysine in metal–organic frameworks

R. Bueno-Perez, A. Martin-Calvo, P. Gómez-Álvarez, J. J. Gutiérrez-Sevillano, P. J. Merkling, T. J. H. Vlugt, T. S. van Erp, D. Dubbeldam and S. Calero, Chem. Commun., 2014, 50, 10849
DOI: 10.1039/C4CC03745F

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