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Issue 80, 2014
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Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

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Abstract

Copper ions are essential for many biological processes. However, high concentrations of copper can be detrimental to the cell or organism. A novel naphthalimide derivative bearing a monoboronic acid group (BNP) was investigated as a Cu2+ selective fluorescent sensor in living cells. This derivative is one of the rare examples of reversible fluorescent chemosensors for Cu2+ which uses a boronic acid group for a binding site. Moreover, the adduct BNP–Cu2+ displays a fluorescence enhancement with fructose. The uptake of this novel compound in HeLa cancer cells was imaged using confocal fluorescence microscopy techniques including two-photon fluorescence lifetime imaging microscopy.

Graphical abstract: Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(ii)

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Publication details

The article was received on 07 May 2014, accepted on 03 Jun 2014 and first published on 04 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC03453H
Chem. Commun., 2014,50, 11806-11809
  • Open access: Creative Commons BY license
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    Ditopic boronic acid and imine-based naphthalimide fluorescence sensor for copper(II)

    M. Li, H. Ge, R. L. Arrowsmith, V. Mirabello, S. W. Botchway, W. Zhu, S. I. Pascu and T. D. James, Chem. Commun., 2014, 50, 11806
    DOI: 10.1039/C4CC03453H

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