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Issue 74, 2014
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Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(iv)-oxo compounds

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Abstract

A structural synthetic model of the iron(IV)-oxo-halide active species of non-heme iron dependent halogenases is reported. Compounds with general formula [FeIV(O)(X)(Pytacn)]+ (1-X, X = Cl, Br) have been prepared and characterized spectroscopically and chemically with regard to their oxidizing ability. 1-X performs hydrogen-atom abstraction of C–H bonds at reaction rates 2–3 times faster than the corresponding solvato dicationic species, thus modelling the first step in C–H functionalization taking place in natural halogenation.

Graphical abstract: Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(iv)-oxo compounds

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Article information


Submitted
30 Apr 2014
Accepted
22 Jul 2014
First published
22 Jul 2014

Chem. Commun., 2014,50, 10887-10890
Article type
Communication

Structural modeling of iron halogenases: synthesis and reactivity of halide-iron(IV)-oxo compounds

O. Planas, M. Clémancey, J. Latour, A. Company and M. Costas, Chem. Commun., 2014, 50, 10887
DOI: 10.1039/C4CC03234A

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