Issue 55, 2014

Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

Abstract

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

Graphical abstract: Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

Supplementary files

Article information

Article type
Communication
Submitted
15 Apr 2014
Accepted
15 May 2014
First published
15 May 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 7254-7257

Author version available

Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells

G. A. Eggimann, E. Blattes, S. Buschor, R. Biswas, S. M. Kammer, T. Darbre and J. Reymond, Chem. Commun., 2014, 50, 7254 DOI: 10.1039/C4CC02780A

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