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Issue 63, 2014
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A lock-and-key mechanism for the controllable fabrication of DNA origami structures

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Abstract

Controllable fabrication of DNA origami structures was achieved using cationic comb-type copolymers (CCCs) as locks and polyvinyl sulphonic acid (PVS) as a key. A CCC binds to the phosphate backbone of either M13mp18/staples alone or both together and restricts origami folding, while PVS unlocks the CCC, restoring the formation of origami structures.

Graphical abstract: A lock-and-key mechanism for the controllable fabrication of DNA origami structures

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Publication details

The article was received on 26 Mar 2014, accepted on 05 Jun 2014 and first published on 05 Jun 2014


Article type: Communication
DOI: 10.1039/C4CC02244K
Chem. Commun., 2014,50, 8743-8746

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    A lock-and-key mechanism for the controllable fabrication of DNA origami structures

    A. Rajendran, M. Endo, K. Hidaka, N. Shimada, A. Maruyama and H. Sugiyama, Chem. Commun., 2014, 50, 8743
    DOI: 10.1039/C4CC02244K

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