Issue 62, 2014
From the journal:

Chemical Communications

Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides†

Na Fei,a   Daniel Häussinger,a   Seraina Blümli,a   Benoît-Joseph Laventie,b   Lorenzo D. Bizzini,a   Kaspar Zimmermann,a   Urs Jenalb  and  Dennis Gillingham*a  

* Corresponding authors

a Department of Chemistry, University of Basel, St. Johanns-Ring 19, Basel, Switzerland
E-mail: dennis.gillingham@unibas.ch

b Biozentrum, University of Basel, Klingelbergstrasse 50/70, Basel, Switzerland

Abstract

We describe a simple method for the direct modification of nucleobases in cyclic purine dinucleotides, important signalling molecules in both prokaryotes and eukaryotes. The method tolerates all members of the cyclic dinucleotide family and could be used to modulate their function or introduce useful side-chains such as fluorophores and photo-crosslinking groups.

Graphical abstract: Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

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Article information

DOI
https://doi.org/10.1039/C4CC01919A
Article type
Communication
Submitted
14 Mar 2014
Accepted
24 May 2014
First published
20 Jun 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 8499-8502

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Catalytic carbene transfer allows the direct customization of cyclic purine dinucleotides

N. Fei, D. Häussinger, S. Blümli, B. Laventie, L. D. Bizzini, K. Zimmermann, U. Jenal and D. Gillingham, Chem. Commun., 2014, 50, 8499 DOI: 10.1039/C4CC01919A

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