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Issue 46, 2014
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Hoechst tagging: a modular strategy to design synthetic fluorescent probes for live-cell nucleus imaging

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Abstract

We report a general strategy to create small-molecule fluorescent probes for the nucleus in living cells. Our strategy is based on the attachment of the DNA-binding Hoechst compound to a fluorophore of interest. Using this approach, simple fluorescein, BODIPY, and rhodamine dyes were readily converted to novel turn-on fluorescent nucleus-imaging probes.

Graphical abstract: Hoechst tagging: a modular strategy to design synthetic fluorescent probes for live-cell nucleus imaging

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Article information


Submitted
08 Mar 2014
Accepted
16 Apr 2014
First published
28 Apr 2014

Chem. Commun., 2014,50, 6149-6152
Article type
Communication

Hoechst tagging: a modular strategy to design synthetic fluorescent probes for live-cell nucleus imaging

A. Nakamura, K. Takigawa, Y. Kurishita, K. Kuwata, M. Ishida, Y. Shimoda, I. Hamachi and S. Tsukiji, Chem. Commun., 2014, 50, 6149
DOI: 10.1039/C4CC01753F

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