Jump to main content
Jump to site search

Issue 80, 2014
Previous Article Next Article

Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

Author affiliations

Abstract

Hydrogen sulfide (H2S) is a newly recognized signaling molecule with very potent cytoprotective actions. The fields of H2S physiology and pharmacology have been rapidly growing in recent years, but a number of fundamental issues must be addressed to advance our understanding of the biology and clinical potential of H2S in the future. Hydrogen sulfide releasing agents (also known as H2S donors) have been widely used in these fields. These compounds are not only useful research tools, but also potential therapeutic agents. It is therefore important to study the chemistry and pharmacology of exogenous H2S and to be aware of the limitations associated with the choice of donors used to generate H2S in vitro and in vivo. In this review we summarized the developments and limitations of currently available donors including H2S gas, sulfide salts, garlic-derived sulfur compounds, Lawesson's reagent/analogs, 1,2-dithiole-3-thiones, thiol-activated donors, photo-caged donors, and thioamino acids. Some biological applications of these donors were also discussed.

Graphical abstract: Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

Back to tab navigation

Publication details

The article was received on 05 Feb 2014, accepted on 04 Jul 2014 and first published on 04 Jul 2014


Article type: Feature Article
DOI: 10.1039/C4CC00968A
Author version
available:
Download author version (PDF)
Chem. Commun., 2014,50, 11788-11805

  •   Request permissions

    Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications

    Y. Zhao, T. D. Biggs and M. Xian, Chem. Commun., 2014, 50, 11788
    DOI: 10.1039/C4CC00968A

Search articles by author

Spotlight

Advertisements