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Issue 27, 2014
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Visible light photoredox-catalysed intermolecular radical addition of α-halo amides to olefins

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Abstract

We present α-chloro amides as a new class of α-acetyl radical precursors, which undergo a tin-free, photoredox-catalysed intermolecular α-alkylation with various olefins exclusively in an anti-Markovnikov fashion. The reaction represents a reductive atom transfer radical addition (ATRA) and provides a series of alkylated amides in good yields.

Graphical abstract: Visible light photoredox-catalysed intermolecular radical addition of α-halo amides to olefins

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Publication details

The article was received on 28 Jan 2014, accepted on 10 Feb 2014 and first published on 26 Feb 2014


Article type: Communication
DOI: 10.1039/C4CC00753K
Chem. Commun., 2014,50, 3619-3622

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    Visible light photoredox-catalysed intermolecular radical addition of α-halo amides to olefins

    M. Nakajima, Q. Lefebvre and M. Rueping, Chem. Commun., 2014, 50, 3619
    DOI: 10.1039/C4CC00753K

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