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Issue 22, 2014
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A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

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Abstract

A clickable and cell-permeable affinity-based probe (AfBP) was designed from staurosporine, by incorporating an electrophilic chloroacetamide warhead to facilitate in situ proteome labeling of a range of potential kinase targets.

Graphical abstract: A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

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Supplementary files

Article information


Submitted
09 Jan 2014
Accepted
28 Jan 2014
First published
28 Jan 2014

Chem. Commun., 2014,50, 2851-2853
Article type
Communication

A tuned affinity-based staurosporine probe for in situ profiling of protein kinases

X. Cheng, L. Li, M. Uttamchandani and S. Q. Yao, Chem. Commun., 2014, 50, 2851
DOI: 10.1039/C4CC00184B

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