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Issue 27, 2014
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Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

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Abstract

DNA methylation has the potential to be a clinically important biomarker in cancer. This communication reports a real-time and label-free biosensing strategy for DNA methylation detection in the cancer cell line. This has been achieved by using surface plasmon resonance biosensing combined with the highly specific molecular inversion probe based amplification method, which requires only 50 ng of bisulfite treated genomic DNA.

Graphical abstract: Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

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Publication details

The article was received on 19 Dec 2013, accepted on 11 Feb 2014 and first published on 11 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC49607D
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Chem. Commun., 2014,50, 3585-3588

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    Molecular inversion probe-based SPR biosensing for specific, label-free and real-time detection of regional DNA methylation

    L. G. Carrascosa, A. A. I. Sina, R. Palanisamy, B. Sepulveda, M. A. Otte, S. Rauf, M. J. A. Shiddiky and M. Trau, Chem. Commun., 2014, 50, 3585
    DOI: 10.1039/C3CC49607D

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