Issue 28, 2014

Carbon monoxide – physiology, detection and controlled release


Carbon monoxide (CO) is increasingly recognized as a cell-signalling molecule akin to nitric oxide (NO). CO has attracted particular attention as a potential therapeutic agent because of its reported anti-hypertensive, anti-inflammatory and cell-protective effects. We discuss recent progress in identifying new effector systems and elucidating the mechanisms of action of CO on, e.g., ion channels, as well as the design of novel methods to monitor CO in cellular environments. We also report on recent developments in the area of CO-releasing molecules (CORMs) and materials for controlled CO application. Novel triggers for CO release, metal carbonyls and degradation mechanisms of CORMs are highlighted. In addition, potential formulations of CORMs for targeted CO release are discussed.

Graphical abstract: Carbon monoxide – physiology, detection and controlled release

Article information

Article type
Feature Article
03 Dec 2013
30 Jan 2014
First published
21 Feb 2014
This article is Open Access
Creative Commons BY license

Chem. Commun., 2014,50, 3644-3660

Author version available

Carbon monoxide – physiology, detection and controlled release

S. H. Heinemann, T. Hoshi, M. Westerhausen and A. Schiller, Chem. Commun., 2014, 50, 3644 DOI: 10.1039/C3CC49196J

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