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Issue 46, 2014
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Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

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Abstract

An efficient and sustainable biocatalytic route for the synthesis of important 17-α-amino steroids has been developed using an ω-transaminase variant from Arthrobacter sp. Optimisation of the reaction conditions facilitated the synthesis of these valuable synthons on a preparative scale, affording excellent isolated yields and stereocontrol.

Graphical abstract: Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

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Supplementary files

Article information


Submitted
28 Nov 2013
Accepted
14 Feb 2014
First published
19 Feb 2014

This article is Open Access

Chem. Commun., 2014,50, 6098-6100
Article type
Communication
Author version available

Synthesis of pharmaceutically relevant 17-α-amino steroids using an ω-transaminase

N. Richter, R. C. Simon, W. Kroutil, J. M. Ward and H. C. Hailes, Chem. Commun., 2014, 50, 6098
DOI: 10.1039/C3CC49080G

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