Issue 19, 2014
From the journal:

Chemical Communications

Conjugation of vitamin E analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy†

Kogularamanan Suntharalingam,‡a   Ying Song‡a  and  Stephen J. Lippard*a  

* Corresponding authors

a Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
E-mail: lippard@mit.edu
Fax: +1 617 258 8150
Tel: +1 617 253 1892

Abstract

We report two platinum(IV) complexes conjugated with a vitamin E analog, α-tocopherol succinate (α-TOS). One of the conjugates displays the activity of both cisplatin and α-TOS in cancer cells, causing damage to DNA and mitochondria simultaneously. Accordingly, it serves as a promising dual-targeting anticancer agent.

Graphical abstract: Conjugation of vitamin E analog α-TOS to Pt(iv) complexes for dual-targeting anticancer therapy

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Article information

DOI
https://doi.org/10.1039/C3CC48740G
Article type
Communication
Submitted
15 Nov 2013
Accepted
10 Dec 2013
First published
11 Dec 2013

Chem. Commun., 2014,50, 2465-2468

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Conjugation of vitamin E analog α-TOS to Pt(IV) complexes for dual-targeting anticancer therapy

K. Suntharalingam, Y. Song and S. J. Lippard, Chem. Commun., 2014, 50, 2465 DOI: 10.1039/C3CC48740G

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