Issue 11, 2014

Construction of DNA–polymer hybrids using intercalation interactions

Abstract

Reversible addition–fragmentation chain transfer (RAFT) polymerisation was used to produce a range of polymers terminated with an acridine group, which intercalates efficiently into dsDNA; the structure of the polymer determines the nature and strength of the interaction. Using a short 63 base pair dsDNA, discrete and well-defined DNA–polymer hybrid nanoparticles were formed, which were characterised by dynamic light scattering, small-angle X-ray scattering and atomic force microscopy.

Graphical abstract: Construction of DNA–polymer hybrids using intercalation interactions

Supplementary files

Article information

Article type
Communication
Submitted
15 Nov 2013
Accepted
09 Dec 2013
First published
17 Dec 2013

Chem. Commun., 2014,50, 1338-1340

Construction of DNA–polymer hybrids using intercalation interactions

T. R. Wilks, A. Pitto-Barry, N. Kirby, E. Stulz and R. K. O'Reilly, Chem. Commun., 2014, 50, 1338 DOI: 10.1039/C3CC48726A

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