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Issue 3, 2014
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A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

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Abstract

Ru(bpy)2dppz, a well studied “light-switch” metal complex, transforms into a photochemical “light-switch” and DNA damaging agent by incorporating structural strain. This distorted compound is photoreactive and ejects a ligand upon binding duplex and G-quadruplex DNA, producing a reactive metal center that metalates the DNA.

Graphical abstract: A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

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Submitted
23 Sep 2013
Accepted
01 Nov 2013
First published
05 Nov 2013

Chem. Commun., 2014,50, 311-313
Article type
Communication

A new type of DNA “light-switch”: a dual photochemical sensor and metalating agent for duplex and G-quadruplex DNA

E. Wachter, B. S. Howerton, E. C. Hall, S. Parkin and E. C. Glazer, Chem. Commun., 2014, 50, 311
DOI: 10.1039/C3CC47269H

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