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Issue 24, 2014
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Copper-promoted reductive homocoupling of quasi-aromatic iron(II) clathrochelates: boosting the inhibitory activity in a transcription assay

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Abstract

A copper-promoted reductive homocoupling reaction, for the first time used for a metal complex, allowed obtaining a new kind of complexes with the encapsulated metal ions, C–C conjugated bis-clathrochelates. These compounds demonstrate extremely high transcription inhibition activity in the T7 RNA polymerase system with values of IC50 reaching as low as the submicromolar range, which places them among the most potent metal-based transcription inhibitors.

Graphical abstract: Copper-promoted reductive homocoupling of quasi-aromatic iron(ii) clathrochelates: boosting the inhibitory activity in a transcription assay

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Publication details

The article was received on 13 Sep 2013, accepted on 31 Jan 2014 and first published on 03 Feb 2014


Article type: Communication
DOI: 10.1039/C3CC47018K
Chem. Commun., 2014,50, 3166-3168

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    Copper-promoted reductive homocoupling of quasi-aromatic iron(II) clathrochelates: boosting the inhibitory activity in a transcription assay

    O. A. Varzatskii, V. V. Novikov, S. V. Shulga, A. S. Belov, A. V. Vologzhanina, V. V. Negrutska, I. Y. Dubey, Yu. N. Bubnov and Ya. Z. Voloshin, Chem. Commun., 2014, 50, 3166
    DOI: 10.1039/C3CC47018K

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