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Issue 16, 2014
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Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions

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Abstract

An orthogonal coupling strategy was developed by combining thiol–ene and SN2 reactions, which was subsequently applied to the accelerated synthesis of multifunctional dendrimers using carbohydrate building blocks. In surface plasmon resonance (SPR) studies, the β-D-galactopyranoside-coated dendrimer exhibited nM binding affinity with the bacterial LecA lectin extracted from Pseudomonas aeruginosa.

Graphical abstract: Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions

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Publication details

The article was received on 29 Aug 2013, accepted on 10 Dec 2013 and first published on 12 Dec 2013


Article type: Communication
DOI: 10.1039/C3CC46633G
Chem. Commun., 2014,50, 1983-1985

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    Efficient and accelerated growth of multifunctional dendrimers using orthogonal thiol–ene and SN2 reactions

    N. Kottari, Y. M. Chabre, T. C. Shiao, R. Rej and R. Roy, Chem. Commun., 2014, 50, 1983
    DOI: 10.1039/C3CC46633G

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