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Issue 2, 2014
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In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

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Abstract

A water-soluble azide-functionalised chitosan was crosslinked with propiolic acid ester-functional poly(ethylene glycol) using copper-free click chemistry. The resultant hydrogel materials were formed within 5–60 min at 37 °C and resulted in mechanically robust materials with tuneable properties such as swelling, mechanical strength and degradation. Importantly, the hydrogels supported mesenchymal stem cell attachment and proliferation and were also non-toxic to encapsulated cells. As such these studies indicate that the hydrogels have potential to be used as injectable biomaterials for tissue engineering.

Graphical abstract: In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

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Supplementary files

Article information


Submitted
26 Jun 2013
Accepted
20 Sep 2013
First published
04 Oct 2013

This article is Open Access

Biomater. Sci., 2014,2, 167-175
Article type
Paper

In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

V. X. Truong, M. P. Ablett, H. T. J. Gilbert, J. Bowen, S. M. Richardson, J. A. Hoyland and A. P. Dove, Biomater. Sci., 2014, 2, 167
DOI: 10.1039/C3BM60159E

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