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Issue 21, 2014
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Induction of formation and conformational conversion of DNA G-quadruplexes by fangchinoline

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Abstract

A natural flexible cyclic molecule, fangchinoline (FAN) from traditional Chinese medicine, was found with a good binding affinity and thermodynamic stabilization effect on a bcl2 G-quadruplex. Further studies showed that fangchinoline could induce the formation and the conformational conversion of G-quadruplexes from a mixed parallel/anti-parallel to a parallel stranded structure. Our study provided a novel G-quadruplex ligand facilitating the structural conversion of the G-quadruplex, which implied that this fangchinoline could be used to regulate biological activities of the G-quadruplex DNA.

Graphical abstract: Induction of formation and conformational conversion of DNA G-quadruplexes by fangchinoline

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Publication details

The article was received on 10 Aug 2014, accepted on 12 Sep 2014 and first published on 12 Sep 2014


Article type: Paper
DOI: 10.1039/C4AY01881H
Anal. Methods, 2014,6, 8476-8481

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    Induction of formation and conformational conversion of DNA G-quadruplexes by fangchinoline

    W. Tan, H. Chen, J. Zhou, M. Xu and G. Yuan, Anal. Methods, 2014, 6, 8476
    DOI: 10.1039/C4AY01881H

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