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Issue 18, 2014
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Electrochemical determination of selected neurotransmitters at electrodes modified with oppositely charged carbon nanoparticles

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Abstract

The electrocatalytic oxidation of neurotransmitters on the electrodes modified with oppositely charged carbon nanoparticles has been investigated. These nanoparticles were deposited at the electrode from the aqueous suspensions via a layer-by-layer method. The electrocatalytic response was evaluated by cyclic voltammetry, differential pulse voltammetry, and chronoamperometry. The modified electrode exhibited good electrocatalytic properties towards not only dopamine oxidation, but also for epinephrine and serotonin oxidation. This allows us to separate their voltammetric signals from the signals of interfering substances such as ascorbic acid or uric acid. The obtained calibration curves are in the range 0.4–350 μM, 1–49 μM and 0.8–100 μM with detection limits of 0.4 μM, 1.0 μM and 0.8 μM for dopamine, epinephrine and serotonin, respectively. In addition these carbon nanoparticulate electrodes showed excellent sample to sample reproducibility (the relative standard deviations for n = 7 equal 0.7%) and, maintained 94% of electrochemical signal corresponding to dopamine oxidation after 18 month storage.

Graphical abstract: Electrochemical determination of selected neurotransmitters at electrodes modified with oppositely charged carbon nanoparticles

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Supplementary files

Article information


Submitted
05 Jun 2014
Accepted
08 Jul 2014
First published
09 Jul 2014

Anal. Methods, 2014,6, 7532-7539
Article type
Paper
Author version available

Electrochemical determination of selected neurotransmitters at electrodes modified with oppositely charged carbon nanoparticles

M. Kundys, K. Szot, E. Rozniecka, M. Jönsson-Niedziółka, R. Lawrence, S. D. Bull, F. Marken and M. Opallo, Anal. Methods, 2014, 6, 7532
DOI: 10.1039/C4AY01344A

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