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Issue 16, 2014
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Time-gated fluorescence sensor for silver ions using Mn:CdS/ZnS quantum dots/DNA/gold nanoparticle complexes

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Abstract

A fluorescent sensor for the determination of Ag+ by time-gated mode is proposed. The method is based on Ag+-induced formation of quantum dot/DNA/gold nanoparticle complexes. Two ssDNA strands (strand A and strand B) are designed which contain C–C mismatched base pairs that can specifically react with Ag+. The water-soluble long-lifetime fluorescence quantum dots (Mn:CdS/ZnS) functionalized with strand A are selected as the fluorophore. The gold nanoparticles (GNPs) which are labeled with strand B, acted as the quencher. When Ag+ is absent in the sample solution, DNA-modified GNPs and Mn:CdS/ZnS were in the freedom state, the fluorescence signal of Mn:CdS/ZnS is obviously strong. When Ag+ are present in the sample solution, a DNA duplex is formed because of the strong binding ability between Ag+ and cytosine bases and formed stable C–Ag+–C structures. As a result, the Mn:CdS/ZnS and the GNPs are brought into close proximity, which caused the fluorescence quenching of the Mn:CdS/ZnS due to the nanometal surface energy transfer (NSET) between the Mn:CdS/ZnS and GNPs. This fluorescent sensor could present a satisfactory specificity and selectivity for Ag+. Meanwhile, the detection limit of Ag+ was estimated to be 7.9 nM.

Graphical abstract: Time-gated fluorescence sensor for silver ions using Mn:CdS/ZnS quantum dots/DNA/gold nanoparticle complexes

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Publication details

The article was received on 29 Nov 2013, accepted on 10 Mar 2014 and first published on 11 Mar 2014


Article type: Paper
DOI: 10.1039/C3AY42129E
Anal. Methods, 2014,6, 6265-6270

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    Time-gated fluorescence sensor for silver ions using Mn:CdS/ZnS quantum dots/DNA/gold nanoparticle complexes

    X. Leng, D. Huang, C. Niu, X. Wang, G. Zeng and Q. Niu, Anal. Methods, 2014, 6, 6265
    DOI: 10.1039/C3AY42129E

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