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Issue 20, 2014
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13C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response

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Abstract

13C-engineered carbon quantum dots (13C-QDs) were used as magnetic resonance (MR) and fluorescence dual-response probe. The enhanced 13C-MR signal was observed at 171 ppm from carboxylic and carboxyl carbons in 13C-QDs with 160-fold improvement on signal-to-noise ratio even when no hyperpolarization was applied, whereas the intrinsic fluorescence of C-QDs was still maintained. The stable MR and fluorescence dual-response was successfully used for long-term observation of zebrafish embryonic development. Cross-validation between MR and fluorescence confirmed the distribution of 13C-QD in zebrafish. 13C-MR provides specific information about the presence, magnitude, and progression of 13C-QDs by defining MR intensity, whereas fluorescence reveals the location of 13C-QDs with its high sensitivity. 13C-MR and fluorescence was simultaneously observed within 13C-QDs, and this work may expand the applications of isotope-engineered nanomaterials.

Graphical abstract: 13C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response

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Publication details

The article was received on 02 Jul 2014, accepted on 29 Jul 2014 and first published on 29 Jul 2014


Article type: Paper
DOI: 10.1039/C4AN01194E
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Analyst, 2014,139, 5134-5139

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    13C-engineered carbon quantum dots for in vivo magnetic resonance and fluorescence dual-response

    Y. Xu, Y. Li, Y. Wang, J. Cui, X. Yin, X. He and Y. Zhang, Analyst, 2014, 139, 5134
    DOI: 10.1039/C4AN01194E

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