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Issue 19, 2014
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High efficiency tandem mass spectrometry analysis using dual linear ion traps

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Abstract

Tandem mass spectrometry (MS/MS) plays an essential role in modern chemical analysis. It is used for differentiating isomers and isobars and suppressing chemical noise, which allows high precision quantitation. The MS/MS analysis has been typically applied by isolating the target precursor ions, while disregarding other ions, followed by a fragmentation process that produces the product ions. In this study, configurations of dual linear ion traps were explored to develop high efficiency MS/MS analysis. The ions trapped in the first linear ion trap were axially, mass-selectively transferred to the second linear ion trap for MS/MS analysis. Ions from multiple compounds simultaneously introduced into the mass spectrometer could be sequentially analyzed. This development enables highly efficient use of the sample. For miniature ion trap mass spectrometers with discontinuous atmospheric pressure interfaces, the analysis speed and the quantitation precision can be significantly improved.

Graphical abstract: High efficiency tandem mass spectrometry analysis using dual linear ion traps

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Supplementary files

Article information


Submitted
13 Jun 2014
Accepted
18 Jul 2014
First published
18 Jul 2014

Analyst, 2014,139, 4779-4784
Article type
Communication
Author version available

High efficiency tandem mass spectrometry analysis using dual linear ion traps

L. Li, X. Zhou, J. W. Hager and Z. Ouyang, Analyst, 2014, 139, 4779
DOI: 10.1039/C4AN01070A

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