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Issue 19, 2014
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Detection of strep throat causing bacterium directly from medical swabs by touch spray-mass spectrometry

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Abstract

Strep throat causing Streptococcus pyogenes was detected in vitro and in simulated clinical samples by performing touch spray ionization-mass spectrometry. MS analysis took only seconds to reveal characteristic bacterial and human lipids. Medical swabs were used as the substrate for ambient ionization. This work constitutes the initial step in developing a non-invasive MS-based test for clinical diagnosis of strep throat. It is limited to the single species, S. pyogenes, which is responsible for the vast majority of cases. The method is complementary to and, with further testing, a potential alternative to current methods of point-of-care detection of S. pyogenes.

Graphical abstract: Detection of strep throat causing bacterium directly from medical swabs by touch spray-mass spectrometry

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Supplementary files

Article information


Submitted
27 May 2014
Accepted
24 Jul 2014
First published
24 Jul 2014

Analyst, 2014,139, 4785-4789
Article type
Communication
Author version available

Detection of strep throat causing bacterium directly from medical swabs by touch spray-mass spectrometry

A. K. Jarmusch, V. Pirro, K. S. Kerian and R. G. Cooks, Analyst, 2014, 139, 4785
DOI: 10.1039/C4AN00959B

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